GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs13315871 | 1 | rs71311871 | chr3:58420613 | PXK | chr3:58318617-58410878:+ | 0.35 | 5.94 | 5.37E-9 | Cholesterol, total |
| THCA | cis | rs13315871 | 1 | rs71311873 | chr3:58447106 | PXK | chr3:58318617-58410878:+ | 0.36 | 6.2 | 1.24E-9 | Cholesterol, total |
| THCA | cis | rs79243044 | 1 | rs7131305 | chr11:5567735 | UBQLNL | chr11:5535624-5537956:- | -0.27 | -6.16 | 1.55E-9 | QRS duration in Tripanosoma cruzi seropositivity |
| THCA | cis | rs4765219 | 1 | rs7131882 | chr12:124426736 | ZNF664 | chr12:124457670-124499967:+ | -0.18 | -5.02 | 7.43E-7 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs7849270 | 1 | rs713219 | chr9:131900920 | CRAT | chr9:131857075-131873070:- | 0.29 | 6.92 | 1.47E-11 | Blood metabolite ratios |
| THCA | cis | rs13053817 | 1 | rs71324766 | chr22:29839659 | NIPSNAP1 | chr22:29950800-29977144:- | 0.3 | 3.89 | 0.000115 | Carotid atherosclerosis in HIV infection |
| THCA | cis | rs13053817 | 1 | rs71324766 | chr22:29839659 | THOC5 | chr22:29904157-29949736:- | 0.2 | 3.61 | 0.000334 | Carotid atherosclerosis in HIV infection |
| THCA | cis | rs4765219 | 1 | rs7132655 | chr12:124438973 | ZNF664 | chr12:124457670-124499967:+ | -0.18 | -5.13 | 4.32E-7 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs71327718 | 1 | rs71327718 | chr3:125592857 | LOC100125556 | chr3:125635444-125648865:+ | 0.68 | 9.92 | 3.33E-21 | Metabolite levels (HVA/5-HIAA ratio) |
| THCA | cis | rs13053817 | 1 | rs71329486 | chr22:29831208 | NIPSNAP1 | chr22:29950800-29977144:- | 0.29 | 3.86 | 0.00013 | Carotid atherosclerosis in HIV infection |
| THCA | cis | rs13053817 | 1 | rs71329486 | chr22:29831208 | THOC5 | chr22:29904157-29949736:- | 0.18 | 3.4 | 0.000739 | Carotid atherosclerosis in HIV infection |
| THCA | cis | rs13053817 | 1 | rs71329487 | chr22:29833469 | NIPSNAP1 | chr22:29950800-29977144:- | 0.28 | 3.71 | 0.000228 | Carotid atherosclerosis in HIV infection |
| THCA | cis | rs13053817 | 1 | rs71329487 | chr22:29833469 | THOC5 | chr22:29904157-29949736:- | 0.19 | 3.52 | 0.000473 | Carotid atherosclerosis in HIV infection |
| THCA | cis | rs10862219 | 1 | rs7133079 | chr12:81439523 | ACSS3 | chr12:81471809-81649582:+ | 0.22 | 4.67 | 4.01E-6 | Neuroticism |
| THCA | cis | rs7134594 | 1 | rs7134594 | chr12:110000193 | KCTD10 | chr12:109886460-109915155:- | -0.23 | -5.91 | 6.66E-9 | HDL cholesterol |